Infant Gut Microbiome Research
The first 1,000 days of life are critical for shaping a child's lifelong health, and the infant gut microbiome plays a central role in this process. At birth, an infant's gut is colonized by microorganisms that influence digestion, immune development, and even responses to vaccinations. The method of delivery (vaginal birth or cesarean section) and early nutrition choices, such as breastfeeding or formula feeding, significantly affect the infant's microbial composition.
Infant Health
The first 1,000 days of life are critical for shaping a child's lifelong health, and the infant gut microbiome plays a central role in this process. At birth, an infant's gut is colonized by microorganisms that influence digestion, immune development, and even responses to vaccinations. The method of delivery (vaginal birth or cesarean section) and early nutrition choices, such as breastfeeding or formula feeding, significantly affect the infant's microbial composition.
Comprehensive Infant Gut Microbiome Testing Services
At Cmbio, our expertise in infant health supports both academic and industrial clients in uncovering the complexities of the infant gut microbiome. We provide insights into how nutritional interventions, such as prebiotics (Human Milk Oligosaccharides) and probiotics, influence microbial colonization and function.
Our custom-developed analysis tools, showcased in publications co-authored with our clients (1-6), can assess how interventions like probiotics or HMOs in formula shift the microbiome. This approach includes clonal-level resolution profiling to differentiate between probiotic strains and naturally occurring strains in the infant gut.
Our Infant Gut Microbiome Testing Process
Our multi-omics approach provides an in-depth look at the baby's microbiomes:
Sample Collection
- Safe, reliable collection of infant fecal samples, ideal for both clinical and research settings.
Advanced Analysis
- Deep shotgun metagenomics for thorough microbial profiling.
- Marker gene analysis to identify key gut microbes and their roles.
- Metabolomics to measure critical metabolites like human milk oligosaccharides, short-chain fatty acids, and tryptophan metabolites linked to gut health.
Lab Insights & Reporting
- Functional profiling to understand how specific bacteria use HMOs and support optimal health.
- Strain tracking and engraftment analysis, separating beneficial bacteria from harmful bacteria strains.
- Community typing and microbiome age prediction to chart baby’s health journey.
- A detailed sample report with actionable results and clear next steps for better immune system development and monitoring overall health.
Services for Infant Gut Microbiome Studies
We offer advanced multi-omics services to help you explore the infant microbiome at multiple levels. Our capabilities include:
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Shotgun metagenomics and marker gene analysis for deep microbial profiling.
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Metabolomics to analyze key metabolites like HMOs, short-chain fatty acids, and tryptophan metabolites, which are critical for gut health and development.
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Functional profiling to understand how specific species utilize HMOs and how these metabolic pathways influence infant health.
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Strain tracking and engraftment to distinguish between probiotic and endogenous strains and examine strain-level differences.
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Infant fecal community typing and microbiome age prediction to analyze shifts in microbiome and infant development
Why Choose Cmbio Infant Gut Microbiome Testing Services?
Choosing Cmbio gives access to:
- Customisable testing and multi-omics reporting for your specific needs.
- Expertise in linking microbiome composition, immune system, and health outcomes, including in preterm birth and respiratory infections research.
- Peer-reviewed, client-trusted tools capable of tracking beneficial and harmful bacteria at a clonal level.
- Ongoing support for future research, product development, or clinical practice based on world-class lab analysis.
Partner with Cmbio for evidence-based insights into your baby’s gut health and solutions to support better health from the start.
References
- Bosheva M, Tokodi I, Krasnow A, Pedersen HK, Lukjancenko O, Eklund AC, Grathwohl D, Sprenger N, Berger B, Cercamondi CI; 5 HMO Study Investigator Consortium. Infant Formula With a Specific Blend of Five Human Milk Oligosaccharides Drives the Gut Microbiota Development and Improves Gut Maturation Markers: A Randomized Controlled Trial. Front Nutr. 2022 Jul 6;9:920362. doi: 10.3389/fnut.2022.920362. PMID: 35873420; PMCID: PMC9298649.
- Holst AQ, Myers P, Rodríguez-García P, Hermes GDA, Melsaether C, Baker A, Jensen SR, Parschat K. Infant Formula Supplemented with Five Human Milk Oligosaccharides Shifts the Fecal Microbiome of Formula-Fed Infants Closer to That of Breastfed Infants. Nutrients. 2023 Jul 10;15(14):3087. doi: 10.3390/nu15143087. PMID: 37513505; PMCID: PMC10383262.
- Boulangé CL, Pedersen HK, Martin FP, Siegwald L, Pallejà Caro A, Eklund AC, Jia W, Zhang H, Berger B, Sprenger N, Heine RG, Cinnamon Study Investigator Group. An Extensively Hydrolyzed Formula Supplemented with Two Human Milk Oligosaccharides Modifies the Fecal Microbiome and Metabolome in Infants with Cow's Milk Protein Allergy. Int J Mol Sci. 2023 Jul 13;24(14):11422. doi: 10.3390/ijms241411422. PMID: 37511184; PMCID: PMC10379726.
- Gold MS, Quinn PJ, Campbell DE, Peake J, Smart J, Robinson M, O'Sullivan M, Vogt JK, Pedersen HK, Liu X, Pazirandeh-Micol E, Heine RG. Effects of an Amino Acid-Based Formula Supplemented with Two Human Milk Oligosaccharides on Growth, Tolerability, Safety, and Gut Microbiome in Infants with Cow's Milk Protein Allergy. Nutrients. 2022 May 30;14(11):2297. doi: 10.3390/nu14112297. PMID: 35684099; PMCID: PMC9182596.
- Martin FP, Tytgat HLP, Krogh Pedersen H, Moine D, Eklund AC, Berger B, Sprenger N. Host-microbial co-metabolites modulated by human milk oligosaccharides relate to reduced risk of respiratory tract infections. Front Nutr. 2022 Aug 4;9:935711. doi: 10.3389/fnut.2022.935711. PMID: 35990340; PMCID: PMC9386273.
- Wallingford JC, Neve Myers P, Barber CM. Effects of addition of 2-fucosyllactose to infant formula on growth and specific pathways of utilization by Bifidobacterium in healthy term infants. Front Nutr. 2022 Sep 23;9:961526. doi: 10.3389/fnut.2022.961526. PMID: 36211486; PMCID: PMC9539000.
Ready to transform your approach to infant health and research? Contact us today to unlock new insights into infant health.
What Our Clients Say
"... offers a suite of sequencing services that we have utilized to generate high quality metagenomic and transcriptomic data for deep microbiome-host analyses."
"... helped us regain the pace of our translational microbiome studies. Their user interface for data analysis is a great tool for teams that need bioinformatic and analytic support."
"... the industry leader in accurate microbiome analysis, was the obvious choice for this co-development partnership."
"We've been using CosmosID-HUB for our analysis needs and it allows for detailed analysis used to answer important clinical questions."