Oral Microbiome Testing

The oral microbiome is crucial in maintaining oral health and serves as a gateway to the rest of the body, impacting the respiratory and gut microbiomes. Its balance is not only fundamental for dental and gum health, but it also impacts systemic health conditions, including immune function and inflammation. At Cmbio, we offer advanced tools to analyze the oral microbiome’s composition and activity, delivering insights to support diagnostics, targeted treatments, and preventive care for both oral and overall health.

Oral Health

The oral microbiome is crucial in maintaining oral health and serves as a gateway to the rest of the body, impacting the respiratory and gut microbiomes. As such, its microbiome is not only essential for oral health but is also critical to overall systemic health. At Cmbio, we provide tools to analyze the oral microbiome’s composition and functions, offering insights that can aid in developing diagnostics, treatments, and preventive care for oral health.

Comprehensive Oral Microbiome Testing Services

Supported by years of expertise with large research cohorts, our oral microbiome testing services deliver:

  • Saliva sample testing, alongside plaque and oral swabs, for a complete oral microbiome profile.
  • Analysis of microbial communities and their activity within the mouth for actionable insights.
  • Identification of key microbial markers linked to oral health problems and systemic health conditions such as gum disease, gum inflammation, and even mouth cancer.

Advanced Oral Microbiome Testing Methods

 

Shotgun Metagenomics with CHAMP

Our CHAMP microbiome profiler shows superior accuracy and sensitivity in benchmarks for detecting and quantifying the diverse bacterial species present in the oral microbiome. Used for shotgun metagenomics, CHAMP offers both taxonomic and functional insights, allowing for the detection of microbial shifts linked to oral health conditions such as periodontitis and dental caries.

A digitalised visual representing a DNA spiral
 

Long-Read Marker Gene Analysis

Our long-read 16S analysis offers a fast and cost-effective approach for mapping the taxonomic composition in the oral microbiome. This method enables precise identification of microbial communities, making it especially valuable for characterizing low-abundance species critical to oral health.

Macro shot of a sampling tool used in laboratories
 

Metabolomics

Our metabolomics services include both untargeted metabolomics, ideal for analyzing a broad range of metabolites simultaneously, and specifically targeted panels with absolute quantification tailored to particular research needs. This approach provides a comprehensive profile of microbial metabolites in the oral cavity, delivering insights into how microbial metabolism affects the oral ecosystem.

Fluorescent microscopy image with cellular structures in red and blue
 

Functional Analysis

Our functional profiling leverages KEGG modules to explore the metabolic potential of the oral microbiome. We provide data on microbial functions by analyzing specific pathways related to oral health.

A woman during her dental exam
 

Cross-body microbiome tracking

Using our CHAMP profiler across all human studies allows for direct comparability of species-level data between the oral and gut microbiomes. Combined with our clonal-level SNV-based profiling, we achieve strain-level resolution, enabling us to track specific bacterial strains between the oral and gut environments. This approach provides unique knowledge about how oral bacteria may influence or integrate with gut microbiota, enhancing our understanding of microbial interactions across body sites.

A dental surgeon reviewing panoramic mouth xrays pointing at a misplaced wisdom tooth within the gum

Our Oral Microbiome Testing Process

Below is an overview of our streamlined testing process, designed to identify the relative abundance and composition of microbes impacting oral and systemic health:

  • Step 1: Collect a saliva sample

    • Simple, non-invasive collection in the comfort of your home or clinic.

  • Step 2: Laboratory analysis

    • Your sample is processed using advanced sequencing and metabolomics platforms.

  • Step 3: Microbial profiling

    • Detailed results provide an oral microbiome profile, including bacteria, fungi, and relevant metabolites linked to oral health issues.

  • Step 4: Functional and comparative analysis

    • Test results highlight key microbial functions, abundance, and risk assessments for gum disease, gum inflammation, and more.

  • Step 5: Actionable insights

    • Cmbio’s reporting enables identification of the root cause of problems and guides strategies to improve oral health, reduce systemic risks, and optimize the host-microbe relationship.

Why Choose Cmbio Oral Microbiome Testing Services?

  • Industry-leading accuracy and sensitivity from proprietary profiling technologies.
  • Deep expertise with large research cohorts for robust, reliable results.
  • Solutions for both diagnostic and preventive care to improve oral and overall health.
  • Direct applications for human health: Vital insights for tackling gum disease, oral cancers, and integrating oral care into whole-body wellness strategies.
A scientist testing probes in a laboratory

Ready to transform your approach to oral health or research? Contact us today to book your oral microbiome testing service and unlock new insights into the oral ecosystem.