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Neurology and Mental Health

The connection between the brain and the gut, often called the gut-brain axis, has been shown to play an important role in influencing mental health and neurological functions. New research suggests that the gut microbiome impacts everything from mood and cognition to the development and progression of neurological disorders such as depression, anxiety, and neurodegenerative diseases. Some of this interaction is mediated by microbial metabolites such as short-chain fatty acids (SCFAs) and tryptophan metabolites, which in turn influence neurotransmitter production and brain function.

 

Neurology and Mental Health

The connection between the brain and the gut, often called the gut-brain axis, has been shown to play an important role in influencing mental health and neurological functions. New research suggests that the gut microbiome impacts everything from mood and cognition to the development and progression of neurological disorders such as depression, anxiety, and neurodegenerative diseases. Some of this interaction is mediated by microbial metabolites such as short-chain fatty acids (SCFAs) and tryptophan metabolites, which in turn influence neurotransmitter production and brain function.

 

Our Expertise in Neurology and Mental Health Microbiome Studies

At Cmbio, we have expertise in analyzing the microbiome for neurology and mental health research. Our services help you examine the gut-brain axis, understand its effects on mental health, and provide actionable insights for your research or therapeutic development.
 

Shotgun Metagenomics

Shotgun metagenomics is the gold standard for human microbiome studies. In unbiased benchmarking experiments, our CHAMP microbiome profiler has been shown to be extremely sensitive and accurate. CHAMP provides both taxonomic and functional composition, enabling you to detect and quantify both common and rare microbial species with high accuracy.

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Functional profiling of Gut-brain Modules

By utilising curated gut-brain modules which we have annotated to our CHAMP database, we can assess specific microbial functions related to the gut-brain axis, such as neurotransmitter biosynthesis pathways and microbial metabolites that interact with the nervous system.

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Targeted Metabolomics Analysis

We provide targeted panels to analyze key metabolites involved in the gut-brain interaction, including short-chain fatty acids (SCFAs) and tryptophan metabolites. These metabolites are known to modulate inflammation, mood, and neural activity, making them critical markers in mental health research. Our targeted panels provide absolute quantification of metabolites.

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Untargeted Metabolomics Analysis

Our untargeted metabolomics panels offer a broad-spectrum approach covering an extensive range of metabolites. This is ideal for exploratory analysis, allowing researchers to identify not only well-studied compounds but also lesser-known metabolites that may be involved in neurological conditions and mental health. By analyzing a wide array of metabolites, our untargeted approach can reveal unexpected pathways and biomarkers linked to health, supporting hypothesis generation and uncovering new potential associations between the microbiome and neurological or mental health conditions.

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Multi-omics Integration

By combining metagenomics, metabolomics, host transcriptomics, and more, we offer a full spectrum of insights into the interplay between the microbiome and neurological and mental health. This approach allows you to correlate microbiome activity with clinical symptoms and disease progression in mental health, and analyzing multiple types of data brings you closer to uncovering the mode of action.

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