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Oral Health

The oral microbiome is crucial in maintaining oral health and serves as a gateway to the rest of the body, impacting the respiratory and gut microbiomes. As such, its microbiome is not only essential for oral health but is also critical to overall systemic health. At Cmbio, we provide tools to analyze the oral microbiome’s composition and functions, offering insights that can aid in developing diagnostics, treatments, and preventive care for oral health.

Our Expertise in Oral Microbiome Research

With a wealth of expertise from oral microbiome studies, including big cohorts, we offer a suite of services tailored to the specific needs of oral health research. These services provide a comprehensive view of microbial composition and functionality in the oral cavity, whether your samples are saliva, plaques, or swabs.
 

Shotgun Metagenomics with CHAMP

Our CHAMP microbiome profiler shows superior accuracy and sensitivity in benchmarks for detecting and quantifying the diverse bacterial species present in the oral microbiome. Used for shotgun metagenomics, CHAMP offers both taxonomic and functional insights, allowing for the detection of microbial shifts linked to oral health conditions such as periodontitis and dental caries.

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Long-Read Marker Gene Analysis

Our long-read 16S analysis offers a fast and cost-effective approach for mapping the taxonomic composition in the oral microbiome. This method enables precise identification of microbial communities, making it especially valuable for characterizing low-abundance species critical to oral health.

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Metabolomics

Our metabolomics services include both untargeted metabolomics, ideal for analyzing a broad range of metabolites simultaneously, and specifically targeted panels with absolute quantification tailored to particular research needs. This approach provides a comprehensive profile of microbial metabolites in the oral cavity, delivering insights into how microbial metabolism affects the oral ecosystem.

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Functional Analysis

Our functional profiling leverages KEGG modules to explore the metabolic potential of the oral microbiome. We provide data on microbial functions by analyzing specific pathways related to oral health.

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Cross-body microbiome tracking

Using our CHAMP profiler across all human studies allows for direct comparability of species-level data between the oral and gut microbiomes. Combined with our clonal-level SNV-based profiling, we achieve strain-level resolution, enabling us to track specific bacterial strains between the oral and gut environments. This approach provides unique knowledge about how oral bacteria may influence or integrate with gut microbiota, enhancing our understanding of microbial interactions across body sites.

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